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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of pterygium
ncRNA name hsa-miR-145
ncRNA Category miRNA
Disease name pterygium
Species Homo sapiens
Tissues/Cell_line pterygium samples, corneal rim tissues
Methods qPCR, in situ hybridization, transfection, immunofluorescence, flow cytometry
Expression pattern up-regulated
Functional description miR-145 suppressed MDM2 expression, which subsequently influenced the p53-related cell growth pattern in pterygial epithelium. The regulatory miR-145/MDM2-p53 loop can serve as a potential target for treatment of pterygium.
PubMed ID 29360447
Year 2018
Title MicroRNA regulation of MDM2-p53 loop in pterygium.
Drug-related ncRNA NO

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